Gonadotropic status in adult women with pituitary stalk interruption syndrome
Authors' conclusion
The fertility prognosis in patients with PSIS needs optimization.
Study context
- Population
- Adult women with pituitary stalk interruption syndrome (PSIS), Francewomen with PSIS
- Participants
- 56 women
- Exposure
- Women with PSIS vs age-matched controls
- PSISn = 56
- Outcome
- Pubertal development, evolution of gonadotropic function and fertility
Methodological detailsmulticentre, age-matched controls (CONSTANCES cohort)
- Multicentre
- Age-matched controls (CONSTANCES cohort)
Main finding
As reported in the abstract
- No spontaneous puberty
- 36 of 56
- Ovarian stimulation among those without spontaneous puberty
- 13
- Women with children after ovarian stimulation
- 7 women, 11 children
- Spontaneous puberty
- 20
- Pregnancies in spontaneous-puberty subgroup
- 4 women, 8 pregnancies
- Secondary gonadotropic deficiency in spontaneous-puberty subgroup
- 6
Observational data: associations, not effects.
Further findings
Height · lower with PSIS
P < 0.0001
In a relationship · fewer with PSIS
P = 0.02
| Outcome | PSIS | Controls | P value |
|---|---|---|---|
| Live births (children) per womanFewer children with PSIS | 0.33 | 0.63 | P = 0.04 |
| Blood pressure (systolic/diastolic)Lower with PSIS | mean 111.3/65.9 ± 11.2/8.1 mmHg | mean 118.7/72.1 ± 10.1/7.7 mmHg | P < 0.001 |
Other metabolic parameters
- No significant differences in other metabolic parameters, notably body mass index (BMI) and lipid profile
Employment/academic status
- Not different in the 2 groups
Original publication
Gonadotropic status in adult women with pituitary stalk interruption syndrome. Eur J Endocrinol. Published 10 June 2024. doi:10.
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