Utility of copeptin in predicting non-pathological postoperative polyuria in patients affected by acromegaly undergoing pituitary neurosurgery
An erratum to this article was published (Pituitary, Oct 2024 ↗)
Authors' conclusion
The early assessment of copeptin, in addition to facilitating the rapid identification of individuals at increased risk of developing CDI, could also allow the recognition of subjects with a tendency towards non-pathological polyuria in the postoperative setting, at least in individuals affected by acromegaly.
Study context
- Population
- Acromegaly patients undergoing endoscopic endonasal resection at a University Hospital; pre-existing or post-neurosurgical central diabetes insipidus (CDI) excluded
- Participants
- 15 patients
- Comparison
- Polyuric vs non-polyuric patients after neurosurgery
- Polyuricn = 4
- Primary endpoint
- Changes in postoperative fluid balance correlated with copeptin and GH levels
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Postoperative fluid balance, copeptin and GH · second postoperative day
- Negative fluid balance on second postoperative day
- 11/15
- Developed polyuria
- 4
- Correlation of growth hormone (GH) at T2 with negative total balance
- r = −0.519, p = 0.048
- Copeptin >39.9 pmol/L at T1 predicting postoperative polyuria: sensitivity
- 100%
- Copeptin >39.9 pmol/L at T1 predicting postoperative polyuria: specificity
- 90.9%, p < 0.001
Further findings
| Outcome | P value |
|---|---|
| T1/T3 copeptin ratioHigher in polyuric | P = 0.013 |
Negative fluid balance and remission of acromegaly · 12 months
- Negative fluid balance associated with remission of acromegaly
- P = 0.046
Original publication
Utility of copeptin in predicting non-pathological postoperative polyuria in patients affected by acromegaly undergoing pituitary neurosurgery. Pituitary. Published 7 June 2024. doi:10.
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