Hospital frailty risk score predicts postoperative outcomes after endoscopic endonasal resection of non-functioning pituitary adenomas
Authors' conclusion
Higher HFRS scores are significantly associated with postoperative complications, prolonged LOS, and high hospital charges for patients undergoing pituitary surgery.
Study context
- Population
- Patients with non-functioning pituitary adenomas undergoing endoscopic endonasal resection, 2017–2020; mean age 57.27 ± 12.95 years, 56% male
- Participants
- 172 patients
- Exposure
- Hospital Frailty Risk Score (HFRS) vs other frailty indices for predicting postoperative outcomes
- Outcome
- High-value care outcomes: postoperative complications, extended LOS and high hospital charges
Methodological detailsmultivariate logistic regression, ROC/AUC with DeLong test
- Multivariate logistic regression
- ROC/AUC with DeLong test
Main finding
As reported in the abstract
Association of greater HFRS with high-value care outcomes (multivariate regression)
Postoperative complications, OR per greater HFRS
OR = 1.51
P < 0.001
Extended length of stay (LOS), OR per greater HFRS
OR = 1.17
P = 0.006
High hospital charges, OR per greater HFRS
OR = 1.18
P = 0.004
Observational data: associations, not effects.
Further findings
Discrimination of HFRS (AUC)
- AUC for complications
- 0.82
- AUC for extended LOS
- 0.64
- AUC for higher charges
- 0.63
- HFRS had the highest AUC vs other frailty indices and was the most parsimonious model
Cohort characteristics
- Mean HFRS
- 3.65 ± 3.27
- Postoperative complications
- 5.2%
- Extended LOS
- 23.3%
- High hospital charges
- 25.0%
Original publication
Hospital frailty risk score predicts postoperative outcomes after endoscopic endonasal resection of non-functioning pituitary adenomas. Pituitary. Published 3 February 2025. doi:10.
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