The clinical and metabolic characteristics of children and adolescents with hypothalamic dysfunction: A single‐centre study from China
Authors' conclusion
Intracranial tumour was the most common aetiology in children and adolescents with hypothalamic dysfunction. In addition, these patients presented a worse metabolic profile on average than healthy patients.
Study context
- Population
- Chinese children and adolescents with hypothalamic dysfunction, single medical centre in Beijing, China, 1989–2019
- Participants
- 40 children
- Exposure
- Hypothalamic dysfunction vs sex- and age-matched controls and sex-, age- and body mass index (BMI)-matched controls
- Hypothalamic dysfunctionn = 40
- Outcome
- Aetiology and symptoms of hypothalamic dysfunction
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Intracranial tumour (most common aetiology, especially germ cell tumours)
37.5%
Hypopituitarism
82.5%
Weight gain
72.5%
Central diabetes insipidus
70.0%
Observational data: associations, not effects.
Further findings
Serum ALT, AST, γ-glutamyl transpeptidase, uric acid, total cholesterol, TG and LDL-C
- Significantly higher in hypothalamic dysfunction than sex- and age-matched controls and sex-, age- and BMI-matched controls
- all p < 0.05
Albumin and HDL-C
- Lower in hypothalamic dysfunction than controls
- P < 0.05
Metabolic diseases
- Patients with metabolic diseases
- 95% (38/40)
Incidence of dyslipidaemia and hyperuricemia
- Significantly higher in hypothalamic dysfunction than sex- and age-matched controls and sex-, age- and BMI-matched controls
- both p < 0.05
Original publication
The clinical and metabolic characteristics of children and adolescents with hypothalamic dysfunction: A single‐centre study from China. Clin Endocrinol (Oxf). Published 5 September 2022. doi:10.
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