Obesity Is Associated with Increased 11-Oxyandrogen Serum Concentrations during Puberty
Authors' conclusion
We found increasing 11-OA serum levels throughout all Tanner stages. 11-OAs were observed to be associated with BMI and skinfold thickness, suggesting that overweight and obesity may be associated with pubertal alterations in 11-OA serum levels.
Study context
- Population
- Healthy children aged 6–19 years
- Participants
- 1,054 children1,734 visits
- Outcome
- Association of overweight and obesity with 11-OA serum levels during puberty
Methodological detailsLC-MS/MS quantification of 11-KT, 11-KA4, 11-OHT, 11-OHA4, testosterone, androstenedione and DHEAS; BMI-SDS, skinfold thickness and Tanner stage assessed
- LC-MS/MS quantification of 11-KT, 11-KA4, 11-OHT, 11-OHA4, testosterone, androstenedione and DHEAS; BMI-SDS, skinfold thickness and Tanner stage assessed
Main finding
As reported in the abstract
Association of 11-OAs with BMI (β)
- 11-KT vs BMI, boys ≤13 years
- β = 0.2, p < 0.001
- 11-KA4 vs BMI, boys ≤13 years
- β = 0.16, p < 0.001
- 11-OHA4 vs BMI, boys ≤13 years
- β = 0.12, p = 0.003
- 11-KT vs BMI, girls ≤11 years
- β = 0.1, p = 0.047
- 11-OHT vs BMI, boys ≤13 years
- β = 0.17, p < 0.001
- 11-OHT vs BMI, boys >13 years
- β = 0.14, p = 0.001
- 11-OHT vs BMI, girls ≤11 years
- β = 0.17, p < 0.001
- 11-OHT vs BMI, girls >11 years
- β = 0.18, p < 0.001
Observational data: associations, not effects.
Further findings
11-OA levels during puberty
- Increases in 11-KT, 11-KA4, 11-OHT and 11-OHA4 in boys and girls during puberty
Original publication
Obesity Is Associated with Increased 11-Oxyandrogen Serum Concentrations during Puberty. Horm Res Paediatr. Published 22 July 2024. doi:10.
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