Proteomic biomarkers related to obesity in heart failure with reduced ejection fraction and their associations with outcome
Authors' conclusion
Patients with HFrEF and obesity show distinct proteomic profiles compared to patients with HFrEF without obesity. Obesity-related proteins are independently associated with HF outcome. These proteins carry potential to improve management of obesity-related HF and could be leads for future research.
Study context
- Population
- Patients with heart failure (HF) with reduced ejection fraction (HF with reduced ejection fraction (HFrEF)); 4210 circulating proteins measured
- Participants
- 373 patients
- Exposure
- Obesity vs no obesity
- Obesityn = 96
- Without obesityn = 277reference
- Outcome
- Composite of:
- Cardiovascular mortality
- HF hospitalization
- Left ventricular assist device implantation
- Heart transplantation
- Follow-up
- Median 2.1 (25th-75th percentile: 1.1-2.6) years
Methodological detailsproteomic analysis, aptamer-based multiplex approach, trimonthly blood sampling
- Proteomic analysis
- Aptamer-based multiplex approach
- Trimonthly blood sampling
Main finding
As reported in the abstract
Proteins linked to obesity
141 of 4210
Obesity-related proteins associated with the primary endpoint (PEP)
50 of 141
Proteins (atherosclerosis or hypertrophy) with prognostic information beyond clinical characteristics, NT-proBNP and hs-troponin T
12
Observational data: associations, not effects.
Further findings
PEP
- PEP — PEP overall
- 30% (112/373)
Prevalence of obesity · baseline
- Obesity
- 26% (96/373)
Original publication
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