Human brain proteome-wide association study provides insights into the genetic components of protein abundance in obesity
Authors' conclusion
Our study provides new insights into the genetic component of human brain protein abundance in obesity. The identified proteins represent promising therapeutic targets for future drug development.
Study context
- Population
- Human brain proteomes integrated with genome-wide summary statistics of obesity-related phenotypes (body fat %, trunk fat %, BMI, visceral adipose tissue, waist circumference, WHR; N ranged from 325,153 to 806,834)
- Participants
- 376 vs 198
- Comparison
- ROSMAP vs BANNER
- ROSMAPn = 376
- BANNERn = 198
- Outcome
- Genes whose cis-regulated brain protein abundances were associated with obesity-related traits
Methodological detailscolocalization analyses, discovery and validation datasets, druggability assessment, pathway enrichment analysis
- Colocalization analyses
- Discovery and validation datasets
- Druggability assessment
- Pathway enrichment analysis
Performance
As reported in the abstract
Genes with cis-regulated brain protein abundance associated with obesity
Genes identified
51
Further findings
Pathway enrichment
- Metabolic processes enriched among the 51 genes (e.g., small molecule metabolic process, metabolic pathways)
- 11
Druggability
- Genes with high drug repurposing value
- 14
Transcriptome-level association
- Genes also associated with obesity at the transcriptome level
- 10
Original publication
Human brain proteome-wide association study provides insights into the genetic components of protein abundance in obesity. Int J Obes (Lond). Published 18 July 2024. doi:10.
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