Obesity‐induced tissue alterations resist weight loss: A mechanistic review
Authors' conclusion
Collectively, the tissue adaptations described pose significant challenges to effectively achieving and sustaining weight loss in obesity.
Study context
- Population
- Obesity: WAT, brown adipose tissue (BAT), skeletal muscle and brain
- Outcome
- Obesity-induced tissue alterations that blunt weight loss
Main finding
As reported in the abstract
- Increased adrenergic stimulation and inflammation downregulate β-adrenoreceptors and impair catecholaminergic signalling in adipocytes, disrupting lipolysis, lowering lipid oxidation and thermogenesis and blunting fat loss
- WAT fibrosis associated with worse weight loss outcomes; limiting collagen and laminin-α4 deposition mitigates WAT accumulation, enhances browning and protects against high-fat-diet-induced obesity
- Obesity compromises skeletal muscle mitochondrial oxidative capacity and lipid oxidation, impairing switching between glucose and lipid metabolism; exacerbated by obesity-associated sarcopenia
- Obesity suppresses sarcolipin-induced SERCA activation, reducing oxidative capacity and energy expenditure and increasing adiposity
- In the hypothalamus, obesity and overnutrition impair insulin and leptin signalling, blunting satiety signals and favouring energy conservation and fat retention
- Impaired dopaminergic signalling and diminished striatal responses to nutrient intake in obese animals and humans, tending to persist after weight loss
Original publication
Obesity‐induced tissue alterations resist weight loss: A mechanistic review. Diabetes Obes Metab. Published 8 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →