Hypothalamic Inflammation Improves Through Bariatric Surgery, and Hypothalamic Volume Predicts Short-Term Weight Loss Response in Adults With or Without Type 2 Diabetes
Authors' conclusion
These findings suggest HI improvement after BS and may support a role for HI in modulating the WL response to these interventions.
Study context
- Population
- Adults with obesity with or without T2D undergoing bariatric surgery, and controls; lumbar puncture and 3-T MRI at baseline and 1 year post-surgery72 with obesity
- Participants
- 20 / 52 / 24
- Exposure
- Obesity with or without T2D vs controls; baseline vs 1 year after bariatric surgery
- Obesity with T2Dn = 20
- Obesity without T2Dn = 52
- Controln = 24reference
- Outcome
- Radiological biomarkers of hypothalamic inflammation (hypothalamic mean diffusivity and volume of whole and main subregions) and their association with post-surgery weight loss
- Follow-up
- 1 year post-surgery
Methodological detailscontrolled, pre–post bariatric surgery
- Controlled
- Pre–post bariatric surgery
Main finding
As reported in the abstract
- Obesity and T2D groups vs controls: larger volume and higher mean diffusivity in the hypothalamic tubular inferior region (arcuate nucleus area)
- These alterations were positively associated with baseline anthropometric and metabolic measures and improved after bariatric surgery
- Larger baseline tubular inferior hypothalamic volume independently related to lesser weight loss 1 and 2 years after surgery
Observational data: associations, not effects.
Further findings
CSF large extracellular vesicles enriched for glial and astrocyte markers
- Did not differ among groups and were unrelated to weight loss trajectories
Original publication
Hypothalamic Inflammation Improves Through Bariatric Surgery, and Hypothalamic Volume Predicts Short-Term Weight Loss Response in Adults With or Without Type 2 Diabetes. Diabetes Care. Published 7 May 2024. doi:10.
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