Posterior hypothalamic involvement on pre-operative MRI predicts hypothalamic obesity in craniopharyngiomas
Authors' conclusion
HO appears to be predetermined by tumor involvement in the posterior hypothalamus observed on pre-operative MRI. Posterior HI on pre-operative MRI was also associated with the development of diabetes insipidus after surgery.
Study context
- Population
- Adults (≥18 years) with craniopharyngioma undergoing first transsphenoidal surgical resection, single centre, February 2005–March 2019; no prior surgery or radiation
- Participants
- 45 adults
- Exposure
- Anterior and posterior hypothalamic involvement (HI) vs no HI or anterior HI only on pre-operative MRI
- Ant and post HIn = 22
- No HI or anterior HI onlyn = 13reference
- Outcome
- Body mass index (BMI)
- Follow-up
- Within 2 years post-surgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Post-operative BMI
- Ant and post HI vs No HI or anterior HI only: P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Pre-operative BMIHigher with ant and post HI on pre-operative MRI | P < 0.05 |
| Post-operative BMI by HI on post-op MRI · 13-24 monthsHigher with ant and post HI on post-op MRI | P < 0.01 |
Extent of resection
- Gross total resection
- n = 35 patients
- No significant difference between groups in gross total, subtotal or near total resection
Baseline endocrine function
- No significant difference in adrenal, thyroid or gonadal insufficiency, IGF-1, hyperprolactinemia or diabetes insipidus
Safety
| Outcome | P value |
|---|---|
| Post-operative diabetes insipidus · following surgeryMore common with ant and post HI on pre-operative MRI | P < 0.05 |
Original publication
Posterior hypothalamic involvement on pre-operative MRI predicts hypothalamic obesity in craniopharyngiomas. Pituitary. Published 3 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →