Hypothalamic–pituitary–adrenal axis activity in patients with primary polydipsia compared to healthy controls
Primary result · HPA axis activityResult — go to the resultEstimated difference −3.7 nmol/L 95% CI −5.5 to −1.8Authors' conclusion
Our results suggest no difference in HPA axis activity between patients with primary polydipsia and healthy controls. The observed difference in salivary cortisol levels may be linked to a dilution effect in saliva rather than an altered stress axis considering the other findings.
Study context
- Population
- Patients with primary polydipsia and healthy controls
- Participants
- 34 vs 20
- Comparison
- Primary polydipsia vs healthy controls
- Primary polydipsian = 34
- Healthy controlsn = 20reference
- Primary endpoint
- Difference in hypothalamic-pituitary-adrenal (HPA) axis activity: circadian serum and salivary cortisol, 24-h UFC, cortisol before and after adrenocorticotropic hormone (ACTH) stimulation (Wilcoxon rank-sum test)
Primary result
HPA axis activity
Estimated difference
−3.7 nmol/L
95% CI −5.5 to −1.8
P < 0.001
Primary polydipsiavs Healthy controls
estimated difference −3.7 nmol/L (95% CI −5.5 to −1.8); P < 0.001
As reported in the abstract
Further findings
| Outcome | P value |
|---|---|
| Fasting copeptin (vasopressin suppression)Significantly lower with primary polydipsia | P < 0.01 |
Original publication
Hypothalamic–pituitary–adrenal axis activity in patients with primary polydipsia compared to healthy controls. Clin Endocrinol (Oxf). Published 30 November 2022. doi:10.
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