Obesity and overweight‐related differences in cardiometabolic risk factors in type 1 diabetes
Authors' conclusion
There is a high and rising prevalence of obesity among adult veterans with T1D, and a strong association of obesity with adverse cardiometabolic risk factors remains even in T1D. These trends highlight the need for a better understanding of mechanisms of weight gain in T1D and improved weight management strategies.
Study context
- Population
- Veterans with T1D aged 21–75 years, Veterans Health Administration
- Participants
- 9,712 veterans
- Exposure
- Weight categories
- Outcome
- Prevalence of overweight and obesity
- Follow-up
- 2022-2023
Methodological detailsVeterans Health Administration administrative databases, 2-year intervals from 2016-2017 to 2022-2023, adjusted for age, sex and race/ethnicity
- Veterans Health Administration administrative databases
- 2-year intervals from 2016-2017 to 2022-2023
- Adjusted for age, sex and race/ethnicity
Main finding
As reported in the abstract
Overweight prevalence
39.7%
Obesity prevalence
32.4%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics of overweight and obese vs normal weight veteransOverweight and obese vs Normal weight | P = 0.003 |
| Characteristics of overweight and obese vs normal weight veteransOverweight and obese vs Normal weight | P = 0.024 |
| Characteristics of overweight and obese vs normal weight veteransOverweight and obese vs Normal weight | P < 0.001 |
Trends in prevalence since 2016 · 2016-2017 to 2022-2023
- Prevalence rates have risen steadily since 2016, most notably in those ages 21-39
Characteristics of overweight and obese vs normal weight veterans
- More likely on other cardioprotective medicines
Cardiometabolic risk factors (blood pressure, LDL-C, HDL-C, TG, eGFR)
- Worse at higher weight categories (all p < 0.001), appeared linearly related to body mass index (BMI)
- Age-BMI interactions in several risk factors: younger veterans showed greater changes with rising BMI
- Adjusted for age, sex and race/ethnicity
Original publication
Obesity and overweight‐related differences in cardiometabolic risk factors in type 1 diabetes. Diabetes Obes Metab. Published 22 December 2025. doi:10.
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