Obesity and metabolic syndrome in adults with a 22q11.2 microdeletion
Authors' conclusion
Generalized and abdominal obesity, as well as MetS, appear to be common in adults with 22q11.2 deletion syndrome, emphasizing the importance of careful monitoring from a young age. These findings contribute to the limited knowledge about the association between pathogenic CNVs, obesity, and MetS.
Study context
- Population
- Adults with a typical 22q11.2 deletion; 45.2% male, median age 30.0 (range 17–71) years
- Participants
- 103 adults
- Exposure
- Adults with 22q11.2 deletion vs population-based cohort
- 22q11.2 deletionn = 103
- Outcome
- Prevalence of generalized obesity (BMI ≥ 30 kg/m²), abdominal obesity (WC ≥102 cm males, ≥88 cm females) and MetS (Joint Interim Statement criteria)
Methodological detailscomparison with population-based data
- Comparison with population-based data
Main finding
As reported in the abstract
Prevalence of generalized obesity, abdominal obesity and MetS
Abdominal obesity
P = 0.002
MetS
P < 0.0001
- 22q11.2 deletion vs Population-based: P < 0.0001 — generalized obesity
Observational data: associations, not effects.
Further findings
Correlations of age with body mass index (BMI) and waist circumference (WC) in antipsychotic-naïve subjects
- Age and BMI, r
- 0.54 (P < 0.001)
- Age and WC, r
- 0.60 (P < 0.001)
- Correlations not present in individuals taking antipsychotics
General linear models predicting BMI and WC
- BMI model
- F(5, 97) = 3.083, R2 = 0.137, P = 0.01
- WC model
- F(5, 92) = 5.985, R2 = 0.245, P < 0.001
- Only age individually predictive of outcomes
- P < 0.05 and P < 0.001
Model predicting metabolic syndrome (MetS)
- Model significant
- P < 0.001
- Higher age, only factor associated with MetS, OR
- 1.07 (95% CI 1.03-1.12, P < 0.001)
Original publication
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