Skeletal Effects of Sleeve Gastrectomy, by Sex and Menopausal Status and Compared to Roux-En-Y Gastric Bypass Surgery
Authors' conclusion
Bone mass, microstructure, and strength decrease after SG. Some skeletal parameters change less after SG than after RYGB, while for others we find no evidence for smaller effects after SG. Postmenopausal women may be at the highest risk of skeletal consequences after SG.
Study context
- Population
- Adults with obesity undergoing sleeve gastrectomy (SG) at an academic center
- Participants
- 54 adults
- Exposure
- SG, compared with a previously reported RYGB cohort of identical design
- SGn = 54
- Outcome
- Skeletal changes after SG
- Follow-up
- 12 months
Methodological detailssingle academic center
- Single academic center
Main finding
As reported in the abstract
Total hip areal bone mineral density (aBMD) change
−8.0%
95% CI −9.1%, −6.7%P < 0.01
Observational data: associations, not effects.
Further findings
Mean percentage weight loss · 12 months
- Mean percentage weight loss over 12 months
- 28.8%
Bone turnover markers
- Bone turnover marker levels increased
Total hip aBMD · 12 months
- Total hip aBMD change
- −8.0% (95% CI −9.1%, −6.7%, P < 0.01)
Spinal aBMD and volumetric bone mineral density (vBMD) by sex/menopausal status
- Spinal aBMD and vBMD declines were larger in postmenopausal women than men
Tibial and radial microstructure and tibial estimated strength
- Tibial and radial trabecular and cortical microstructure and tibial estimated strength worsened, particularly in postmenopausal women
SG vs RYGB cohort
- Some SG biochemical, vBMD and radial microstructural changes were smaller; other changes were not
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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