Defining Clinical Characteristics of Individuals With and Without Post‐Bariatric Hypoglycemia After Gastric Bypass
Authors' conclusion
High rates of IBS, dumping symptoms, and orthostatic hypotension suggest disordered autonomic regulation as a potential contributor to PBH. Self-reported preoperative symptoms and family history of hypoglycemia suggest possible preoperative differences in glucose metabolism in PBH.
Study context
- Population
- Adults 18–70 without current diabetes, academic referral centre
- Participants
- 39 / 25 / 17
- Exposure
- Post-bariatric hypoglycemia (PBH) vs RYGB non-hypo vs controls without upper GI surgery
- PBHn = 39
- RYGB non-hypon = 25reference
- Controlsn = 17
- Outcome
- Survey scores and self-reported conditions
Methodological detailsobservational, academic referral centre
- Observational
- Academic referral centre
Main finding
As reported in the abstract
- PBH vs RYGB non-hypo: all p < 0.05 vs. RYGB non-hypo
Observational data: associations, not effects.
Further findings
Hypoglycemia characteristics in PBH
- Level 3 hypoglycemia
- 87%
- Emergency visits
- 28%
- Vehicle accidents
- 8%
- Reduced hypoglycemia awareness
- 82%
- Unaware (modified Clarke/Gold scores)
- 13%-17%
- Preoperative hypoglycemia symptoms
- 26%
- Family history of hypoglycemia
- 18%
Medication use
- Gabapentin and PPI use more frequent in PBH
Original publication
Defining Clinical Characteristics of Individuals With and Without Post‐Bariatric Hypoglycemia After Gastric Bypass. Clin Endocrinol (Oxf). Published 27 November 2024. doi:10.
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