Combined diet and exercise training decreases serum lipids associated with insulin resistance
Authors' conclusion
These data show that serum sphingolipid species previously linked to insulin resistance in humans can be reduced with insulin-sensitizing lifestyle interventions. Furthermore, individuals with elevated serum TAG may significantly benefit from lifestyle interventions that increase insulin sensitivity due to a greater decrease in serum lipids related to insulin resistance.
Study context
- Population
- Individuals with obesity
- Participants
- 21 individuals
- Comparison
- Before vs after 3-month combined weight loss and exercise training
- Lifestyle interventionn = 21
- Outcome
- Changes after intervention
- Follow-up
- 3 months
Methodological details3-month intervention, hyperinsulinemic-euglycemic clamp, serum lipidomics
- 3-month intervention
- Hyperinsulinemic-euglycemic clamp
- Serum lipidomics
Main finding
As reported in the abstract
BMI significantly reduced
10%
VO2peak increased
12%
Insulin sensitivity increased
57%
Further findings
- Higher preintervention triacylglycerol (TAG): significant decreases in serum lipids; lower preintervention TAG: not significantly changed
Original publication
Combined diet and exercise training decreases serum lipids associated with insulin resistance. Obesity (Silver Spring). Published 26 November 2024. doi:10.
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