Hepatic lipogenesis marked by glucokinase regulator (GCKR) ‐modulated triglycerides increases serum FGF21 in children/teens with obesity
Authors' conclusion
Hepatic lipogenesis, marked by GCKR-modulated triglycerides, is significantly associated with increased serum FGF-21 in children/adolescents with obesity.
Study context
- Population
- Children/adolescents with obesity (80 males, 12.7 ± 2.1 years)80 males
- Participants
- 159 participants
- Outcome
- Causal relationship between TG and serum FGF21 (hypothesis: FGF21 induced by TG as compensatory mechanism)
Methodological detailsGCKR Pro446Leu variant as instrumental variable
- GCKR Pro446Leu variant as instrumental variable
Main finding
As reported in the abstract
Associations of GCKR Pro446Leu, TG and FGF21
Pro446Leu variant increased circulating triglycerides (TG)
β = +0.35
p < 0.001
Circulating TG positively associated with circulating FGF21
β = +0.42
p < 0.001
Pro446Leu variant increased FGF21, with the slope expected if association entirely mediated by TG (0.35 × 0.42 = 0.14)
β = +0.14
p = 0.031
Original publication
Hepatic lipogenesis marked by GCKR ‐modulated triglycerides increases serum FGF21 in children/teens with obesity. Diabetes Obes Metab. Published 29 November 2024. doi:10.
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