Number of CAG repeats and mortality in middle aged and older men
Authors' conclusion
Our European-wide cohort data overall found no association of androgen receptor CAG repeat number and mortality in men. However, post hoc analysis suggested that an association might be present in men with lower baseline testosterone concentrations, which merits further investigation.
Study context
- Population
- Men aged 40–79 years recruited across six countries of the European Male Aging Study, 2003–2005; mean baseline age 60 ± 11.1 years
- Participants
- 1,977 men
- Exposure
- Androgen receptor (AR) CAG repeat number <22 or >23 vs 22-23
- Outcome
- All-cause mortality
- Follow-up
- To 27 January 2018; mean 12.2 years
Methodological detailsmultinational, Cox proportional hazards modelling, multivariable model
- Multinational
- Cox proportional hazards modelling
- Multivariable model
Main finding
As reported in the abstract
Each group vs 22-23 CAG repeatsHazard ratio (95% CI)
<22 CAG repeats
1.17(0.93–1.49)
>23 CAG repeats
1.14(0.88–1.47)
- Died at follow-up (all men)
- 25.1%
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| All-cause mortality in lowest tertile of baseline testosterone (<14.2 nmol/L)<22 CAG repeatsvs 22-23 CAG repeatsAdjusted model · post-hoc analysis | 1.49 (0.97–2.27) | |
| All-cause mortality in lowest tertile of baseline testosterone (<14.2 nmol/L)>23 CAG repeatsvs 22-23 CAG repeatsAdjusted model; significant · post-hoc analysis | 1.68 (1.06–2.67) | |
| 0.20.5125Hazard ratio (log scale) |
CAG repeat length distribution · mean baseline
- CAG repeat length range
- 6 to 39
- Most frequent: 21 repeats
- 16.4%
Original publication
Number of CAG repeats and mortality in middle aged and older men. Clin Endocrinol (Oxf). Published 18 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →