Anti‐Mullerian hormone and spontaneous puberty in a diverse US Turner syndrome clinic cohort: A cross‐sectional study
Authors' conclusion
Our institutional data reflects a diverse cohort of patients seen in a TS specialty clinic in the United States, showing correlation of AMH with karyotype and spontaneous menarche, as well as description of gonadotropins during minipuberty highlighting their clinical relevance. Studies in larger, prospective longitudinal cohorts will help determine their predictive value and role in the care of TS.
Study context
- Population
- Patients seen in the Turner syndrome (TS) clinic at Children's National Hospital, 1/1/2019 to 8/24/2022; median age 9.6 year (0.08–22 year)
- Participants
- 114 participants
- Exposure
- Anti-Mullerian Hormone (AMH) by karyotype and spontaneous puberty status
- Outcome
- Distribution of AMH, correlated with spontaneous puberty and karyotype
Methodological detailsretrospective chart review, single-centre
- Retrospective chart review
- Single-centre
Main finding
As reported in the abstract
45,X/46,XX
2.7
mean · ± 0.95 · ng/mL
45,X
0.03
mean · ± 0.14 · ng/mL
Structurally abnormal-X
0.11
mean · ± 0.5
45,X/46,XX vs 45,X: P < 0.001 · 45,X/46,XX vs Structurally abnormal-X: P = 0.0003
- AMH detectable
- (40/104) 38%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| AMH by spontaneous puberty | Spontaneous menarche mean 1.4 ± 1.6 ng/mL |
AMH by spontaneous puberty
- Mean AMH higher with spontaneous menarche vs spontaneous thelarche but no menarche
AMH detectable during minipuberty
- AMH detectable during minipuberty, in those with the lowest luteinizing hormone (LH)
- 2/10
Original publication
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