FSH and Sertoli Cell Biomarkers Accurately Distinguish Hypogonadotropic Hypogonadism From Self-limited Delayed Puberty
An erratum to this article was published (J Clin Endocrinol Metab, 20 Feb 2026 ↗)
Authors' conclusion
Serum FSH combined with inhibin B or AMH is highly predictive to accurately distinguish between SLDP and CHH in adolescent males.
Study context
- Population
- Male adolescents presenting with delayed puberty; final diagnosis self-limited delayed puberty (SLDP) or congenital hypogonadotropic hypogonadism (CHH) at age 18 years or ≥4 years after testis volume reached 4 mLcompleted follow-up · final diagnosis SLDP 33 · or CHH 32
- Participants
- 65 adolescents
- Comparison
- Baseline serum FSH, anti-Müllerian hormone (AMH) and inhibin B vs LH and testosterone to distinguish CHH from SLDP
- Outcome
- Diagnostic performance of baseline serum reproductive hormones for CHH vs SLDP
- Follow-up
- Baseline
Methodological detailsfollowed until final diagnosis by gold-standard criteria
- Followed until final diagnosis by gold-standard criteria
Main finding
As reported in the abstract
Diagnosis of CHH
| Group | Sensitivity | Specificity | Predictive values | Positive likelihood ratio |
|---|---|---|---|---|
| FSH × inhibin B | >93% | ≥92% | >92% | >12 |
| FSH × AMH | >93% | ≥92% | >92% | >12 |
Sensitivity
FSH × inhibin B>93%
FSH × AMH>93%
Specificity
FSH × inhibin B≥92%
FSH × AMH≥92%
Predictive values
FSH × inhibin B>92%
FSH × AMH>92%
Positive likelihood ratio
FSH × inhibin B>12
FSH × AMH>12
Observational data: associations, not effects.
Further findings
Diagnostic performance in patients without red flags (micropenis, cryptorchidism and/or microorchidism)
Original publication
FSH and Sertoli Cell Biomarkers Accurately Distinguish Hypogonadotropic Hypogonadism From Self-limited Delayed Puberty. J Clin Endocrinol Metab. Published 11 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →