Persistently Decreased Quality of Life and its Determinants in Previous Illicit Androgen Users
Authors' conclusion
Previous illicit androgen users exhibited reduced QoL 2 years after androgen discontinuation, which may be a persistent condition.
Study context
- Population
- Men involved in recreational strength training, grouped by history of androgen use; mean (SD) age 33 (8) years
- Participants
- 77 / 118 / 39
- Exposure
- Previous illicit androgen users vs current illicit androgen users vs controls who had never used androgens
- Previous usersn = 77
- Current usersn = 118
- Controlsn = 39reference
- Outcome
- Physical and mental health-related QoL (RAND Short-Form-36 questionnaire)
Main finding
As reported in the abstract
| Group | Mental component summary score, mean (SD) | Physical component summary score (PCS), mean (SD) |
|---|---|---|
| Previous users | 48 (10) | 48 (9) |
| Controls | 54 (4) | 53 (3) |
Mental component summary score, mean (SD)
Previous users48 (10)
Controls54 (4)
Physical component summary score (PCS), mean (SD)
Previous users48 (9)
Controls53 (3)
- Previous users vs Controls: P = 0.004 — Mental component summary score; lower with previous users
- Previous users vs Controls: P = 0.002 — Physical component summary score; lower with previous users
Observational data: associations, not effects.
Further findings
| Outcome | Previous users | Controls | P value |
|---|---|---|---|
| Serum total testosteronePrevious users vs Controls · lower with previous users · median, nmol/L | 14 (IQR 11–17) | 19 (IQR 16–21) | P < 0.001 |
| Duration since androgen cessation | geometric mean 2.0 (95% CI 1.5–2.6) years | — not stated in the abstract |
— not stated in the abstract
Determinants of reduced quality of life (QoL) in previous users (multivariate linear regressions)
- Lower serum total testosterone, longer duration since androgen cessation, recruitment from an endocrine outpatient clinic and established chronic diseases independently associated with reduced QoL
- P < 0.05
Original publication
Persistently Decreased Quality of Life and its Determinants in Previous Illicit Androgen Users. J Clin Endocrinol Metab. Published 14 September 2023. doi:10.
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