Non-linear association of atherogenic index of plasma with insulin resistance and type 2 diabetes: a cross-sectional study
Authors' conclusion
AIP showed an inverse L-shaped association with IR and a J-shaped association with T2D, indicating that AIP should be reduced to a certain level to prevent IR and T2D.
Study context
- Population
- NHANES participants, 2009–2018
- Participants
- 9,245 participants
- Exposure
- Association of AIP with insulin resistance (IR) and T2D
- Outcome
- IR and T2D defined by the 2013 American Diabetes Association guidelines
Methodological detailsNHANES 2009–2018, weighted multivariate linear and logistic regression, generalized additive model, two-part logistic regression
- NHANES 2009–2018
- Weighted multivariate linear and logistic regression
- Generalized additive model
- Two-part logistic regression
Main finding
As reported in the abstract
Estimate (95% CI)
AIP
OR for IR 1.29(1.26–1.32)
AIP
OR for T2D 1.18(1.15–1.22)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Association of AIP with glycaemic measures (adjusted)AIP | β, FPG 0.08 (95% CI 0.06–0.10) | |
| Association of AIP with glycaemic measures (adjusted)AIP · estimate outside its printed CI | β, HbA1c 0.04 (95% CI 0.39–0.58) | |
| Association of AIP with glycaemic measures (adjusted)AIP | β, fasting serum insulin 4.26 (95% CI 3.73–4.79) | |
| Association of AIP with glycaemic measures (adjusted)AIP | β, HOMA-IR 0.22 (95% CI 0.18–0.25) | |
| Subgroup by sexFemale vs Male · association more significant in female | IR: P for interaction = 0.0135 | |
| Subgroup by sexFemale vs Male · association more significant in female | T2D: P for interaction = 0.0024 |
Original publication
Non-linear association of atherogenic index of plasma with insulin resistance and type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol. Published 29 June 2023. doi:10.
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