Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7
Authors' conclusion
These findings support epigenetic mechanisms in the developmental origins of neonatal adiposity and as potential biomarkers of metabolic disease risk.
Study context
- Population
- Newborns; cord blood DNA methylation (791,359 CpG sites after quality control)
- Participants
- 2,740 vs 139
- Exposure
- Hyperglycemia and Adverse Pregnancy Outcome (HAPO) vs Gestation and Growth (Gen3G)
- HAPOn = 2,740
- Gen3Gn = 139
- Outcome
- Association between neonatal adiposity (sum of three skinfold thicknesses) and cord blood DNA methylation
Methodological detailsdiscovery sample (HAPO Study), independent replication cohort (Gen3G), linear regression adjusted for maternal and offspring covariates and cell counts, Illumina EPIC arrays
- Discovery sample (HAPO Study)
- Independent replication cohort (Gen3G)
- Linear regression adjusted for maternal and offspring covariates and cell counts
- Illumina EPIC arrays
Main finding
As reported in the abstract
CpG sites associated with neonatal adiposity
Significant associations in HAPO (Bonferroni-adjusted p < 0.05), CpG sites
89
Associations confirmed in Gen3G replication, CpG sites (incl. IGF1R and KLF7)
7
Observational data: associations, not effects.
Original publication
Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7. Obesity (Silver Spring). Published 20 August 2024. doi:10.
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