Type 2 & other diabetes

New insights in the mechanisms of weight‐loss maintenance: Summary from a Pennington symposium

Obesity (Silver Spring)Published Symposium summary

Study context

Outcome
Mechanisms of weight-loss maintenance
Methodological detailsnarrative review, Pennington Biomedical Scientific Symposium reviewing physiological, behavioral and environmental systems controlling energy intake and expenditure, in the context of weight-loss maintenance
  • Narrative review
  • Pennington Biomedical Scientific Symposium reviewing physiological, behavioral and environmental systems controlling energy intake and expenditure, in the context of weight-loss maintenance

Main finding

As reported in the abstract

  • Lifestyle interventions effectively promote weight loss of 5% to 10%; pharmacological and surgical interventions even more
  • Some novel approved drugs induce up to an average of 25% weight loss
  • Long-term weight-loss maintenance remains extremely challenging; subsequent weight gain is typical
  • Mechanisms underlying weight regain remain to be fully elucidated

Original publication

New insights in the mechanisms of weight‐loss maintenance: Summary from a Pennington symposium. Obesity (Silver Spring). Published 16 October 2023. doi:10.1002/oby.23905

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