Comparison of beta-cell function between Hong Kong Chinese with young-onset type 2 diabetes and late-onset type 2 diabetes
Authors' conclusion
Chinese with YOD had accelerated loss of beta-cell function than those with LOD especially in non-obese individuals.
Study context
- Population
- Hong Kong Chinese with T2D from two cohorts recruited 1996–2012 and 2020–2021two cohorts · two cohorts recruited 1996-2012 4,376 · 2020-2021 794
- Participants
- 1,876 vs 3,294
- Exposure
- Young-onset vs late-onset T2D
- YODn = 1,876
- LODn = 3,294reference
- Outcome
- Beta-cell function: HOMA2-%B and fasting plasma C-peptide across diabetes duration at enrolment
Methodological detailstwo cohorts, multivariable linear regression
- Two cohorts
- Multivariable linear regression
Main finding
As reported in the abstract
HOMA2-%B and fasting plasma C-peptide
- HOMA2-%B and fasting plasma C-peptide lower in YOD vs LOD, consistently among those with BMI < 27.5 kg/m² and HOMA2-IR ≤ 1.6 (median value)
- YOD vs LOD: P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Slope of decline in HOMA2-%B by diabetes duration, BMI < 27.5 kg/m²Greater decline with YOD · cross-sectional | P for interaction = 0.015 |
Baseline characteristics
- Family history of diabetes, YOD vs LOD
- 61.6 % vs 43.6 %
- Obesity, YOD vs LOD
- 41.9 % vs 26.8 %
- Dyslipidaemia, YOD vs LOD
- 61.7 % vs 54.4 %
- Mean HbA1c, YOD vs LOD
- 7.7 % vs 7.4 %
- Age, mean (SD), YOD vs LOD
- 39.9 [7.5] vs 60.8 [10.6] years
- Diabetes duration, median (IQR), YOD vs LOD
- 6 [2-12] vs 5 [1-10] years
Original publication
Comparison of beta-cell function between Hong Kong Chinese with young-onset type 2 diabetes and late-onset type 2 diabetes. Diabetes Res Clin Pract. Published 14 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →