Characteristics of Abdominal Visceral Adipose Tissue, Metabolic Health and the Gut Microbiome in Adults
Authors' conclusion
VAT PDFF measured with MRI is related to impaired glucose homeostasis, dyslipidemia, and differences in the gut microbiome, independently of the total body fat percentage.
Study context
- Population
- Healthy adults (male and female) at a clinical research center
- Participants
- 60 adults
- Outcome
- Associations of VAT PDFF and VAT:SAT PDFF ratio (magnetic resonance imaging (MRI)) with metabolic markers and gut microbiome
Methodological detailsobservational, single clinical research center
- Observational
- Single clinical research center
Main finding
As reported in the abstract
- Higher visceral adipose tissue (VAT) proton density fat fraction (PDFF) and VAT:Subcutaneous adipose tissue (SAT) PDFF ratio related to higher body mass index (BMI), HbA1c, HOMA-IR, non-HDL cholesterol, plasma TG, LDL-C and lower HDL-C
- Higher VAT PDFF and VAT:SAT PDFF ratio associated with lower alpha diversity and altered beta diversity of the gut microbiome
- Differences in VAT associated with higher relative abundance of Firmicutes, lower relative abundance of Bacteroidetes, and enrichment of genera Dorea, Streptococcus and Solobacterium
Observational data: associations, not effects.
Original publication
Characteristics of Abdominal Visceral Adipose Tissue, Metabolic Health and the Gut Microbiome in Adults. J Clin Endocrinol Metab. Published 14 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →