Correlates of Skeletal Muscle Mass and Differences Between Novel Subtypes in Recent-Onset Diabetes
Authors' conclusion
SMM/BMI differs between diabetes subtypes and may contribute to subtype differences in disease progression. Of note, clinical variables rather than biomarkers of inflammation explain most of the variation in SMM/BMI.
Study context
- Population
- Participants with known diabetes duration <1 year, German Diabetes Study (GDS)
- Participants
- 842 participants
- Exposure
- Skeletal muscle mass (SMM)/BMI between novel diabetes subtypes
- Outcome
- Skeletal muscle mass normalized to BMI (SMM/BMI): correlates and differences between novel diabetes subtypes
Main finding
As reported in the abstract
- Male sex and physical activity positively associated with SMM/BMI
- all P < .05
- Age, BMI, HbA1c, HOMA for β-cell function and eGFR inversely associated with SMM/BMI
- all P < .05
- Model r2
- 0.82
- Biomarkers of inflammation correlated with SMM/BMI after adjustment for sex and multiple testing (all P < .0006); largely explained by BMI
- 23 of 79
Observational data: associations, not effects.
Original publication
Correlates of Skeletal Muscle Mass and Differences Between Novel Subtypes in Recent-Onset Diabetes. J Clin Endocrinol Metab. Published 13 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →