Gestational diabetes & diabetes in pregnancy
Neonatal Amino Acids and Acylcarnitines Associated With Maternal Blood Glucose Levels Throughout Pregnancy: Insights From the Beijing Birth Cohort Study
Authors' conclusion
Our findings revealed a significant link between maternal glucose trajectories throughout pregnancy and neonatal arginine and proline metabolism, urea cycle pathway, and fatty acid oxidation pathway. These results highlight the importance of maintaining optimal blood glucose levels throughout pregnancy to promote healthy neonatal metabolic outcomes.
Study context
- Population
- Singleton pregnant women without preexisting diabetes and their neonates born July 2021–October 2022, Beijing Birth Cohort Study, Beijing, China
- Participants
- 11,457 women
- Exposure
- Maternal glucose trajectories: mid-to-late gestational hyperglycemia and early-onset hyperglycemia vs consistent normoglycemia
- Consistent normoglycemian = 8,648reference
- Mid-to-late gestational hyperglycemian = 2,540
- Early-onset hyperglycemian = 269
- Outcome
- Neonatal circulating metabolites: 11 amino acids and 33 acylcarnitines
Methodological detailslatent class trajectory model, adjusted for potential confounders
- Latent class trajectory model
- Adjusted for potential confounders
Main finding
As reported in the abstract
Neonatal amino acids and acylcarnitines by maternal glucose trajectory
- Mid-to-late gestational hyperglycemia: decreased alanine, arginine, ornithine and proline (arginine and proline metabolism and urea cycle pathway)
- Mid-to-late gestational hyperglycemia: increased C4DC+C5-OH; decreased C6DC and C10:1
- Early-onset hyperglycemia: elevated free acylcarnitine and C4DC+C5-OH; decreased C10:1 (fatty acid oxidation pathway)
Observational data: associations, not effects.
Further findings
Associations by neonatal sex
- Associations primarily observed in male rather than female neonates
Original publication
Neonatal Amino Acids and Acylcarnitines Associated With Maternal Blood Glucose Levels Throughout Pregnancy: Insights From the Beijing Birth Cohort Study. Diabetes Care. Published 11 June 2024. doi:10.
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