Musculoskeletal disorders in type 1 diabetes: Clinical phenotyping and associations with quality of life and glucose control - The French SFDT1 cohort study
Authors' conclusion
We have shown that MSDs are found in 1 in 3 people with T1DM. They are associated with several lifestyle factors, diabetes complications and the use of automated insulin delivery systems. MSDs should be considered in the T1DM assessment to optimize quality of life.
Study context
- Population
- Adults with T1D in the French SFDT1 cohort; 53 % men, median age 38 (IQR 22) years
- Participants
- 1,832 adults
- Outcome
- Prevalence of MSDs (stress fractures, non-traumatic upper-limb disorders, entrapment syndromes) and associated factors
Methodological detailscross-sectional analysis of the SFDT1 cohort, multiple imputation for missing data, logistic regression with progressive adjustment
- Cross-sectional analysis of the SFDT1 cohort
- Multiple imputation for missing data
- Logistic regression with progressive adjustment
Main finding
As reported in the abstract
Personal history of ≥1 MSD
At least one MSD
34 %
Stress fractures
8 %
Upper-limb disorders
24 %
Entrapment syndromes
15 %
Observational data: associations, not effects.
Further findings
Factors associated with musculoskeletal disorders (MSDs) (fully adjusted model)
- Current smoking, OR [95 %CI]
- 1.50 [1.14;1.97]
- Non-excessive alcohol consumption, OR [95 %CI]
- 1.45 [1.14;1.85]
- Neuropathy, OR [95 %CI]
- 1.70 [1.35;2.15]
- Retinopathy, OR [95 %CI]
- 1.30 [1.02;1.65]
- Use of AID systems, OR [95 %CI]
- 1.53 [1.06;2.21]
- Fully adjusted model
Global quality of life
- MSDs associated with reduced global quality of life
- 0.97 [0.95;0.98]
HbA1c, social vulnerability, physical activity
- MSDs not associated with HbA1c, social vulnerability or physical activity
Original publication
Musculoskeletal disorders in type 1 diabetes: Clinical phenotyping and associations with quality of life and glucose control - The French SFDT1 cohort study. Diabetes Metab. Published 23 April 2025. doi:10.
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