Severity of complications is associated with impaired health‐related quality of life in people with type 1 diabetes
Authors' conclusion
We observed an inverse association between the severity of complications and overall HRQoL and most of its dimensions. Our results highlight the need to reinforce the prevention of complications to improve the overall well-being of people with T1D.
Study context
- Population
- Adults living with T1D in the French SFDT1 cohort; 48% women, median age 38 (IQR 28; 51) years
- Participants
- 1,892 adults
- Exposure
- Severity of diabetes complications and health-related quality of life (HRQoL)
- Outcome
- HRQoL by generic (EQ-5D-5L) and diabetes-specific (Audit of Diabetes-Dependent Quality of Life) instruments, and its association with complication severity (adapted DCSI)
- Follow-up
- Baseline
Methodological detailscross-sectional analysis of baseline data of a longitudinal cohort (SFDT1), multiple imputation for missing data, multivariable models
- Cross-sectional analysis of baseline data of a longitudinal cohort (SFDT1)
- Multiple imputation for missing data
- Multivariable models
Main finding
As reported in the abstract
Mean overall EQ-5D-5L HRQoL score (maximum 100), ± as printed
71.1 ± 17.7
Median (IQR) Diabetes Complication Score Index (DCSI)
1
0; 2
Decrease in overall EQ-5D-5L HRQoL per one-step increase in DCSI (multivariable models)
1.5%
DCSI inversely associated with domains of the diabetes-specific scale
17 domains
Observational data: associations, not effects.
Further findings
Participants negatively impacted per EQ-5D-5L domain · baseline
- Mobility
- 271 (14%)
- Self-care
- 94 (5%)
- Usual activities
- 378 (19%)
- Pain/discomfort
- 853 (45%)
- Anxiety/depression
- 983 (52%)
Original publication
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