Association Between Muscle Status and Bone Size, Density, and Strength in Type 1 Diabetes: A Cross-sectional Study
Authors' conclusion
We observed a strong association between muscle and bone regardless of T1D status. Overall, the associations did not differ between the T1D and control groups, suggesting that the muscle-bone crosstalk is not affected by T1D.
Study context
- Population
- Danish adults with childhood-onset T1D (onset before age 18 years) and matched controls; median age 43.2 years, BMI 26.9 kg/m²
- Participants
- 111 vs 37
- Exposure
- Adults with childhood-onset T1D vs controls
- T1Dn = 111
- Controlsn = 37reference
- Outcome
- Relationship between muscle mass, muscle strength and bone
Methodological detailssex- and age-matched controls
- Sex- and age-matched controls
Main finding
As reported in the abstract
Muscle–bone associations
Within T1D, appendicular lean mass/height2 associated with femoral neck bone mineral density (BMD) (R2)
0.12
Within T1D, appendicular lean mass/height2 associated with total hip BMD (R2)
0.337
Within T1D, grip strength associated with femoral neck BMD (R2)
0.104
Within T1D, grip strength associated with total hip BMD (R2)
0.137
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Muscle mass and grip strength, T1D vs controlsT1D vs Controls · total lean mass comparable | P = 0.41 |
| Muscle mass and grip strength, T1D vs controlsT1D vs Controls · appendicular lean mass comparable | P = 0.75 |
| Muscle mass and grip strength, T1D vs controlsT1D vs Controls · grip strength comparable | P = 0.52 |
| BMD, bone size (cortical area and perimeter) and bone material strength indexDid not differ | P > 0.05 |
Original publication
Association Between Muscle Status and Bone Size, Density, and Strength in Type 1 Diabetes: A Cross-sectional Study. J Clin Endocrinol Metab. Published 23 April 2025. doi:10.
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