Real‐World Burden of Diabetic Ketoacidosis in Type 1 Diabetes in the French SFDT1 Cohort: The SFDT1 ‐ Diabetic Ketoacidosis (DKA) Study
Authors' conclusion
DKA is a significant acute complication for people with T1D in France, even on AID.
Study context
- Population
- People with T1D in the French SFDT1 cohort; 51.4% male, mean age 36.8 years, mean age at diagnosis 16.1 years, mean T1D duration 20.7 years
- Participants
- 2,685 people
- Outcome
- Proportion of participants with ≥1 DKA events
- Follow-up
- 12 months prior to the index date
Methodological detailsreal-world, based on the French SFDT1 prospective cohort
- Real-world
- Based on the French SFDT1 prospective cohort
Main finding
As reported in the abstract
≥1 DKA events
- Proportion with ≥1 DKA events
- 4.5% (95% CI 3.8%; 5.4%)
- Associated with younger age
- p < 0.001
- Associated with younger age at T1D diagnosis
- p = 0.015
- Associated with shorter T1D duration
- < 0.001
- Associated with higher HbA1c
- p = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| DKA by age group: 18-24 year olds (highest) · 12 months prior to the index date | 18-24 year olds 10.3% (95% CI 7.5%–13.7%) | |
| DKA by insulin delivery · 12 months prior to the index dateAID vs Open-loop | AID 3.1% · Open-loop 5.4% | P = 0.034 |
| DKA by glucose monitoring · 12 months prior to the index dateCGM vs SMBG | CGM 4.3% · SMBG 8.1% | P = 0.034 |
Safety
SHEs in participants with vs without ≥1 DKA events · previous 12 months
P < 0.001
Original publication
Real‐World Burden of Diabetic Ketoacidosis in Type 1 Diabetes in the French SFDT1 Cohort: The SFDT1 ‐ DKA Study. Diabetes Obes Metab. Published 28 September 2026. doi:10.
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