Muscle Quality in Relation to Prediabetes Phenotypes: A Population-Based Study With Mediation Analysis
Authors' conclusion
Muscle quality was impaired in prediabetes and its specific phenotype. Relative to blood glucose, elevated HbA1c might be a better predictor of reduced muscle quality.
Study context
- Population
- General US population, NHANES 2011–2014
- Participants
- 2,351 participants
- Exposure
- Prediabetes and its phenotypes vs normoglycemia
- Prediabetesn = 938
- Normoglycemian = 1,413reference
- Outcome
- Arm muscle quality: dominant grip strength divided by dominant arm muscle mass measured by DXA
Methodological detailspopulation-based, mediation analysis
- Population-based
- Mediation analysis
Main finding
As reported in the abstract
Arm muscle quality
- Arm muscle quality lower in prediabetes and all prediabetes phenotypes (except IGT) than normoglycemia, despite higher grip strength and larger arm muscle mass
- Arm muscle quality unrelated to prediabetes awareness
- Prediabetes vs Normoglycemia: all P < .04
Observational data: associations, not effects.
Further findings
Arm muscle quality and odds of low arm muscle quality by number of glucometabolic defects
- Arm muscle quality decreased and odds of low arm muscle quality increased with increasing numbers of defects (both P < .001)
- Insulin resistance the predominant mediator
HbA1c-defined (IA1c) vs blood glucose-defined prediabetes (IFG, IGT or IFG + IGT)
- IA1c had lower arm muscle quality and higher odds of low arm muscle quality than blood glucose-defined prediabetes
Original publication
Muscle Quality in Relation to Prediabetes Phenotypes: A Population-Based Study With Mediation Analysis. J Clin Endocrinol Metab. Published 25 October 2023. doi:10.
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