Multidimensional feature-based assessment of microcirculatory hemodynamic dysfunction in patients with Wagner Grade 0 diabetic foot
Authors' conclusion
Patients with DF demonstrate a composite pattern of microcirculatory dysfunction characterized by insufficient perfusion, attenuated autonomic regulation, altered rhythmicity, and impaired bilateral coordination. Multidimensional plantar microcirculatory features improve cross-sectional discrimination between DF and non-DF participants, providing a quantitative basis for risk stratification and phenotypic characterization of DF-related microcirculatory abnormalities.
Study context
- Population
- Consecutive participants with and without diabetic foot; microcirculation signals at forefoot MT1 and MT5consecutive
- Participants
- 286 participants
- Exposure
- Diabetic foot (DF) vs non-DF
- DFn = 129
- non-DFn = 157reference
- Outcome
- Discriminative models for DF (ROC-AUC)
Methodological detailsconsecutive participants
- Consecutive participants
Main finding
As reported in the abstract
- AUC, MT1 model
- 0.845
- AUC, MT5 model
- 0.822
- AUC, combined model (MT1 + MT5); outperformed single-site models
- 0.906
- Mean perfusion at MT1 and MT5 significantly lower in DF (largest between-group differences)
- both p < 0.001
Observational data: associations, not effects.
Further findings
Frequency domain and rhythmicity at MT1
- Relative power in neurogenic and myogenic bands at MT1 significantly decreased in DF
- MT1: fewer peaks, prolonged inter-peak intervals, increased dispersion in DF
Symmetry
- Left-right correlation coefficients at both sites decreased in DF
- P < 0.001
- Absolute left-right mean differences did not increase
Original publication
Multidimensional feature-based assessment of microcirculatory hemodynamic dysfunction in patients with Wagner Grade 0 diabetic foot. Diabetes Res Clin Pract. Published 2 February 2026. doi:10.
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