GLP-1 Receptor Agonists Are Associated With Reduced Mortality Following Diabetic Foot Ulcers: A Nationwide Observational Study
Authors' conclusion
One-year mortality after DFU remains high and is strongly linked to age and comorbidities. Community-based identification highlights the vulnerability of these patients, even outside hospital settings. Glucagon-like peptide 1 receptor agonists and structured, multidisciplinary follow-up are associated with better survival and should be prioritized. These findings underline the urgent need to reinforce preventive care and optimize care pathways for high-risk diabetic populations.
Study context
- Population
- Adults with incident (first) diabetic foot ulcer (DFU), January 2017–December 2018, French SNDS; inclusion by hospitalization records and community care data
- Participants
- 133,791 adults
- Outcome
- 1-year mortality following a first DFU (factors associated)
- Follow-up
- 1 year
Methodological detailsnationwide, French National Health Data System (SNDS), Cox proportional hazards models
- Nationwide
- French National Health Data System (SNDS)
- Cox proportional hazards models
Main finding
As reported in the abstract
Died within 1 year
14.6%
Observational data: associations, not effects.
Secondary outcomes
Major amputation · 1 year
- Underwent major amputation
- 3.5%
Mortality after major lower-limb amputation · within a year
- Died within a year among those amputated
- 28.8%
- Similar patterns for postamputation mortality; GLP-1 RA showed a consistent survival benefit
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →