The association between the C-reactive protein-triglyceride-glucose index and all-cause and cardiovascular mortality in patients with diabetic foot: A retrospective cohort study
Authors' conclusion
A higher CTI level was independently associated with an increased risk of all-cause and cardiovascular mortality in patients with diabetic foot. The CTI may serve as a promising and easily accessible risk stratification tool, though its clinical utility requires validation in prospective studies.
Study context
- Population
- Inpatients with diabetic foot, tertiary hospital diabetic foot (DF) department in Tianjin (2020–2021)
- Participants
- 827 inpatients
- Exposure
- High vs low C-reactive protein-triglyceride-glucose index
- Outcome
- All-cause and CVD mortality
- Follow-up
- Median 47 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
High CTIHazard ratio (95% CI)
All-cause mortality; fully adjusted
1.57(1.24–2.00)
CVD mortality; fully adjusted
1.50(1.06–2.11)
- All-cause deaths
- 325
- CVD deaths
- 158
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic splines (RCS)) and predictive accuracy (ROC)
- RCS indicated nonlinear associations
- P < 0.05
- ROC supported CTI's predictive accuracy for mortality
Original publication
The association between the C-reactive protein-triglyceride-glucose index and all-cause and cardiovascular mortality in patients with diabetic foot: A retrospective cohort study. Diabetes Res Clin Pract. Published 28 January 2026. doi:10.
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