Multicenter Analysis of Cardiometabolic-Related Diagnoses in Youth With Congenital Adrenal Hyperplasia: A PEDSnet Study
Authors' conclusion
Overall, youth with CAH are at increased risk of diagnoses related to worse cardiometabolic health.
Study context
- Population
- Youth with congenital adrenal hyperplasia (CAH), 6 PEDSnet sites, EHR data 2009–2019; outcomes among youth over 2 years
- Participants
- 1,647 vs 6,588
- Exposure
- Youth with CAH vs matched controls
- CAHn = 1,647
- Controlsn = 6,588reference
- Outcome
- Odds of cardiometabolic-related diagnoses (based on diagnosis, anthropometric and laboratory data)
Methodological detailsmulticentre, propensity score-matched, electronic health record data
- Multicentre
- Propensity score-matched
- Electronic health record data
Main finding
As reported in the abstract
Cardiometabolic-related diagnoses, all CAH vs matched controls
CAH vs ControlsOdds ratio (95% CI)
Overweight/obesity
3.63(3.24,4.07)
Hypertension
3.07(2.60,3.64)
Dysglycemia
1.95(1.35,2.82)
Dyslipidemia
2.28(1.79,2.91)
Liver dysfunction
2.30(1.91,2.76)
- Median age at last visit, all CAH
- 12.9 years [7.3, 17.6]
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Cardiometabolic-related diagnoses, classic CAH subset (n = 547) vs matched controls (n = 2188)Classic CAHvs ControlsOverweight/obesity | 3.21 (2.61,3.93) | |
| Cardiometabolic-related diagnoses, classic CAH subset (n = 547) vs matched controls (n = 2188)Classic CAHvs ControlsHypertension | 8.22 (6.71,10.08) | |
| Cardiometabolic-related diagnoses, classic CAH subset (n = 547) vs matched controls (n = 2188)Classic CAHvs ControlsLiver dysfunction | 2.11 (1.55,2.89) | |
| 0.050.21520Odds ratio (log scale) |
- Cardiometabolic-related diagnoses, classic CAH subset (n = 547) vs matched controls (n = 2188) — Median age at last visit, classic CAH
- 11.6 years [4.7, 17.5]
- Cardiometabolic-related diagnoses, classic CAH subset (n = 547) vs matched controls (n = 2188): classic CAH: glucocorticoid and mineralocorticoid prescriptions
Original publication
Multicenter Analysis of Cardiometabolic-Related Diagnoses in Youth With Congenital Adrenal Hyperplasia: A PEDSnet Study. J Clin Endocrinol Metab. Published 24 May 2024. doi:10.
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