Biochemical Control in Cushing's Syndrome: Outcomes of the Treatment in a Large Single Center Cohort
Authors' conclusion
Biochemical control can be achieved in most patients with different subtypes of CS within a reasonable time frame. Control of hypercortisolism has improved over time.
Study context
- Population
- Patients with confirmed Cushing's syndrome (CS) treated in a single tertiary care center
- Participants
- 296 patients
- Exposure
- Cushing's disease (CD) vs ectopic Cushing's syndrome (ECS) vs adrenal Cushing's syndrome (ACS)
- CDn = 185
- ECSn = 27
- ACSn = 84
- Outcome
- Biochemical control rates
Methodological detailssingle-centre, tertiary care center
- Single-centre
- Tertiary care center
Main finding
As reported in the abstract
Biochemical control after first-line treatment
Biochemical control after first-line treatment (all patients)
82%
Observational data: associations, not effects.
Further findings
Time to biochemical control — CD vs ACS, ECS · longer in CD
P < 0.05
Disease persistence after first-line therapy — CD vs ECS, ACS · more often in CD
P < 0.05
Disease recurrence after first-line therapy — CD vs ECS, ACS · more often in CD
P < 0.05
Control of hypercortisolism at last follow-up · last follow-up (76 months, 38-163)
- Total time in hypercortisolism since diagnosis, CD diagnosed since 2013 vs before 2013
- P < 0.0070
- Total time in hypercortisolism since diagnosis, CD diagnosed since 2013 vs before 2013: 13.5 weeks vs 26.1 weeks; shorter since 2013, after specialized care implemented
Original publication
Biochemical Control in Cushing's Syndrome: Outcomes of the Treatment in a Large Single Center Cohort. J Clin Endocrinol Metab. Published 20 May 2024. doi:10.
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