Delineating the Psychiatric Morbidity Spectrum in Congenital Adrenal Hyperplasia: A Population-based Registry Study
Authors' conclusion
21-OHD is associated with a significantly increased psychiatric morbidity. This study underlines a need for awareness of mental health in patients with 21-OHD.
Study context
- Population
- Patients with congenital adrenal hyperplasia (CAH) in a national Danish cohort; psychiatric diagnoses from all Danish hospitals 1977–2018 and psychiatric medication prescribed 1995–2018448 CAH patients
- Participants
- 410 / 24 / 44,527
- Exposure
- CAH vs matched general population controls
- 21-OHDn = 410
- Rare forms of CAHn = 24
- Controlsn = 44,527reference
- Outcome
- Psychiatric diagnoses (IRR, negative binomial regression) and psychiatric medication (HR, Cox regression)
Methodological detailspopulation-based, age- and sex-matched controls, national
- Population-based
- Age- and sex-matched controls
- National
Main finding
As reported in the abstract
21-OHD vs ControlsEstimate (CI)
Females; any psychiatric diagnosis
IRR 2.32(1.48–3.64)
Males; any psychiatric diagnosis
IRR 2.74(1.31–5.71)
Females; psychiatric medication
HR 1.74(1.42–2.13)
Males; psychiatric medication
HR 1.74(1.30–2.33)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Rare forms of CAH: any psychiatric diagnosis and psychiatric medicationRare forms of CAHvs ControlsMales; any psychiatric diagnosis; significantly increased | IRR 12.85 (CI 1.78–92.87) | |
| Rare forms of CAH: any psychiatric diagnosis and psychiatric medicationRare forms of CAHvs ControlsFemales; any psychiatric diagnosis; not increased | IRR 0.54 (CI 0.10–3.00) | |
| Rare forms of CAH: any psychiatric diagnosis and psychiatric medicationRare forms of CAHvs ControlsFemales; psychiatric medication; not increased | HR 1.05 (CI 0.39–2.84) | |
| Rare forms of CAH: any psychiatric diagnosis and psychiatric medicationRare forms of CAHvs ControlsMales; psychiatric medication; not increased | HR 0.72 (CI 0.10–5.13) | |
| 0.050.21520Ratio (log scale) |
Original publication
Delineating the Psychiatric Morbidity Spectrum in Congenital Adrenal Hyperplasia: A Population-based Registry Study. J Clin Endocrinol Metab. Published 15 November 2024. doi:10.
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