Mortality risk associated with general and central obesity in inflammatory bowel disease patients: a long-term prospective cohort study
Authors' conclusion
Central obesity and underweight, rather than general obesity, are associated with an increased risk of all-cause mortality in IBD patients. These findings underscore the importance of adequate nutrition and reduced visceral adiposity for long-term prognosis improvement of IBD patients.
Study context
- Population
- Patients with inflammatory bowel disease; mean age 57.0 (SD: 8.0) years; 51.7% female591 all-cause deaths
- Participants
- 5,107 patients
- Exposure
- General and central obesity indices vs reference categories
- Normal body mass index (BMI)n = 1,681reference
- Overweightn = 2,229
- Obesityn = 1,161
- Underweightn = 36
- Outcome
- All-cause death
- Follow-up
- Median 14.6 years'
Methodological detailslong-term, Cox proportional hazards models
- Long-term
- Cox proportional hazards models
Main finding
All-cause mortality by BMI category · median 14.6 years
Hazard ratio
3.22
95% CI 1.70–6.11
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| All-cause mortality by WC quartile · median 14.6 years' follow-upHighest quartilesvs Lowest quartiles34% greater mortality risk | 1.34 (1.02–1.76) | |
| All-cause mortality by WHR quartile · median 14.6 years' follow-upHighest quartilesvs Lowest quartiles56% greater mortality risk | 1.56 (1.13–2.15) | |
| All-cause mortality by weight-adjusted waist index (WWI) quartile · median 14.6 years' follow-upHighest quartilesvs Lowest quartiles64% greater mortality risk | 1.64 (1.24–2.16) | |
| All-cause mortality by conicity index quartile · median 14.6 years' follow-upHighest quartilesvs Lowest quartiles72% greater mortality risk | 1.72 (1.28–2.30) | |
| All-cause mortality by A Body Shape Index (ABSI) quartile · median 14.6 years' follow-upHighest quartilesvs Lowest quartiles64% greater mortality risk | 1.64 (1.23–2.20) | |
| 0.512Hazard ratio (log scale) |
- All-cause mortality by waist circumference (WC) quartile: significant dose-response relationship (all P values < 0.05)
- All-cause mortality by waist-to-hip ratio (WHR) quartile: significant dose-response relationship (all P values < 0.05)
- All-cause mortality by weight-adjusted waist index (WWI) quartile: significant dose-response relationship (all P values < 0.05)
- All-cause mortality by conicity index quartile: significant dose-response relationship (all P values < 0.05)
- All-cause mortality by A Body Shape Index (ABSI) quartile: significant dose-response relationship (all P values < 0.05)
Original publication
Mortality risk associated with general and central obesity in inflammatory bowel disease patients: a long-term prospective cohort study. Int J Obes (Lond). Published 25 August 2025. doi:10.
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