Monocytes perturbation implicated in the association of stress hyperglycemia with postoperative poor prognosis in non-diabetic patients with Stanford type-A acute aortic dissection
Authors' conclusion
Intraoperative stress hyperglycemia, in combination with day-one postoperative monocyte counts, were clinically significant for predicting adverse outcomes in AAD patients undergoing open repair surgery. Elevated glucose concentrations shaped the inflammatory features of monocytes in AAD by impairing mitochondrial functions.
Study context
- Population
- Adults undergoing open surgery for acute aortic dissection (AAD) at two tertiary medical centers in China
- Participants
- 321 adults
- Exposure
- Intraoperative hyperglycemia vs lower time-weighted average glucose (TWAG)
- Outcome
- Incidence and characteristics of perioperative stress hyperglycemia
Methodological detailstwo tertiary medical centres
- Two tertiary medical centres
Main finding
As reported in the abstract
Intraoperative hyperglycemia (TWAG >142 mg/dL)
- Intraoperative hyperglycemia (TWAG >142 mg/dL) associated with elevated postoperative monocyte counts and inflammatory cytokines, which correlated with extended intensive care unit (ICU) stays and worsened outcomes
Observational data: associations, not effects.
Secondary outcomes
In vitro high glucose effects on monocytes
- High glucose induced mitochondrial impairment in monocytes, increased release of inflammatory cytokines and the proportion of classical monocytes from AAD patients
Original publication
Monocytes perturbation implicated in the association of stress hyperglycemia with postoperative poor prognosis in non-diabetic patients with Stanford type-A acute aortic dissection. Cardiovasc Diabetol. Published 26 October 2024. doi:10.
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