Obesity cardiomyopathy could contribute to sudden cardiac death: a Japanese epidemiological morphological study
Authors' conclusion
The prevalence of OCM may be higher than expected in Japan, and this may be a specific pathological finding. Given that approximately half the cases of OCM were due to SCD, OCM may cause SCD, emphasizing the need to recognise and diagnose OCM.
Study context
- Population
- Autopsy cases in Japan
- Participants
- 294 autopsy cases
- Exposure
- Obesity cardiomyopathy (OCM) vs obesity without cardiac hypertrophy (OB) vs normal-weight controls
- OCMn = 19
- Outcome
- Prevalence of OCM
Main finding
As reported in the abstract
OCM
6.5%
19
Observational data: associations, not effects.
Further findings
Median, g
| Outcome | OCM | OB |
|---|---|---|
| Heart weight | 435 (IQR 408–515) | 360 (IQR 341–385) |
- Age · OCM vs non-OCM · OCM slightly younger
- P = 0.081
Heart weight
- Heart weight significantly heavier in OCM than OB
Morphology
- OCM hearts had a "globoid" appearance with a thickened right ventricular outflow tract
- Some OCM cases showed focal interstitial fibrosis in the left ventricle
Sudden cardiac death (SCD)
- Approximately half the OCM cases diagnosed with SCD, with significant differences
Original publication
Obesity cardiomyopathy could contribute to sudden cardiac death: a Japanese epidemiological morphological study. Cardiovasc Diabetol. Published 24 October 2024. doi:10.
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