MG53 does not mark cardiovascular risk and all-cause mortality in subjects with type 2 diabetes: A prospective, observational study
Authors' conclusion
MG53 does not mark the cardiovascular risk profile neither predict long-term mortality in Caucasian T2D individuals.
Study context
- Population
- Caucasian individuals with T2D, MIND.IT study
- Participants
- 296 vs 234
- Exposure
- Baseline serum MG53 levels in relation to cardiovascular risk profile and all-cause mortality
- T2Dn = 296
- Healthyn = 234reference
- Outcome
- All-cause mortality and cardiovascular risk profile in relation to baseline MG53 levels
- Follow-up
- 17-years follow up
Methodological detailslongitudinal, 17-year follow-up
- Longitudinal
- 17-year follow-up
Main finding
As reported in the abstract
- MG53 directly related to HbA1c (r2 0.029)
- p = 0.006
- MG53 directly related to systolic BP (r2 0.032)
- p = 0.004
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| MG53 levels, T2D vs healthy reference cohort · baselineHigher with T2D | P < 0.001 |
| MG53 levels, T2D women vs men · baselineHigher in women | P = 0.001 |
Original publication
MG53 does not mark cardiovascular risk and all-cause mortality in subjects with type 2 diabetes: A prospective, observational study. Diabetes Res Clin Pract. Published 24 September 2023. doi:10.
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