Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
Authors' conclusion
Our study identified plasma metabolites associated with prospective renal function decline, offering insights into the underlying mechanism by which the metabolite abnormalities due to fatty acid oversupply might reflect impaired β-oxidation and associate with future chronic kidney disease progression in individuals with diabetes.
Study context
- Population
- Multi-ancestral individuals with T2D in Singapore
- Participants
- 5,144 individuals
- Outcome
- eGFR slope (kidney function decline)
Methodological detailsmetabolomic analysis, genome-wide association studies on metabolites, colocalisation analysis
- Metabolomic analysis
- Genome-wide association studies on metabolites
- Colocalisation analysis
Main finding
As reported in the abstract
Elevated lipids with long unsaturated fatty acid chains (e.g. phosphatidylethanolamines, triacylglycerols, diacylglycerols, ceramides, deoxysphingolipids) associated with more rapid kidney function decline
61 lipids
Elevated amino acids associated with slower eGFR decline
7 amino acids
Elevated lipids associated with slower eGFR decline
3 lipids
Observational data: associations, not effects.
Further findings
- Metabolite quantitative trait loci associated with these metabolites
- 15
- Variants near TM6SF2, APOE and CPS1 could affect both metabolite levels and kidney functions
Original publication
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