Cutaneous Carbonyl Stress Is Associated With Nerve Dysfunction in Recent-Onset Type 2 Diabetes
Authors' conclusion
Cutaneous AGE markers were associated with neurophysiological deficits in recent-onset type 2 diabetes and predicted their progression after 5 years, substantiating the role of carbonyl stress in the development of early DSPN.
Study context
- Population
- Individuals with recent-onset (≤12 months) T2D and with normal glucose tolerance (NGT) from the German Diabetes Study baseline cohortT2D subgroup n = 80 reassessed at 5 years
- Participants
- 160 vs 144
- Exposure
- Recent-onset T2D vs NGT
- T2Dn = 160
- NGTn = 144reference
- Outcome
- Argpyrimidine area (skin biopsy)
- Follow-up
- Baseline
Methodological detailsGerman Diabetes Study baseline cohort, skin biopsies, 5-year reassessment of subgroup
- German Diabetes Study baseline cohort
- Skin biopsies
- 5-year reassessment of subgroup
Main finding
As reported in the abstract
P < 0.05
Observational data: associations, not effects.
Further findings
Correlations of AGE autofluorescence in T2D · baseline
- AGE autofluorescence vs peroneal motor nerve conduction velocity (inverse), T2D
- r = −0.346
- AGE autofluorescence vs AGE reader measurements, T2D
- r = 0.358
- No such correlations in NGT
- All P < 0.05
Prediction of 5-year progression in T2D subgroup
- Higher baseline AGE autofluorescence and lower endothelial cell area predicted deterioration of clinical and neurophysiological measures
Original publication
Cutaneous Carbonyl Stress Is Associated With Nerve Dysfunction in Recent-Onset Type 2 Diabetes. Diabetes Care. Published 25 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →