Metabolic Syndrome Traits Increase the Risk of Major Adverse Liver Outcomes in Type 2 Diabetes
Authors' conclusion
Having or acquiring additional traits of MetS increase the rate of progression to MALOs in patients with T2D. These results could be used to inform screening initiatives for liver disease.
Study context
- Population
- Patients with T2D without a history of liver disease, Swedish national registers 1998–2021; median age 64 years, 58% male
- Participants
- 230,992 patients
- Exposure
- More than one metabolic syndrome (MetS) trait vs one MetS trait at baseline
- Outcome
- Major adverse liver outcomes (MALOs), including cirrhosis and its complications
- Follow-up
- Median 9.9 years
Methodological detailsnationwide registers, Cox regression models
- Nationwide registers
- Cox regression models
Main finding
As reported in the abstract
MALOs
Adjusted hazard ratio (95% CI)
>1 MetS traitvs 1 MetS trait (only T2D)
2.33(1.53–3.54)
Per added MetS traitper added trait
1.28(1.23–1.33)
- Developed major adverse liver outcomes (MALOs) (whole cohort)
- 3,215 (1.39%)
Observational data: associations, not effects.
Further findings
MetS trait with largest association with incident MALOs: hypertension
| aHR (95% CI) | ||
|---|---|---|
| Hypertension | 2.06 (1.57–2.71) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Acquisition of additional MetS traits during follow-up
- Patients who acquired additional MetS traits had a progressively higher rate of MALOs
Original publication
Metabolic Syndrome Traits Increase the Risk of Major Adverse Liver Outcomes in Type 2 Diabetes. Diabetes Care. Published 18 March 2024. doi:10.
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