Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
Authors' conclusion
The association profiles for galectin-1 and galectin-3 indicate overlapping metabolic effects in humans, while the distinctly different associations seen with fat mass, fat distribution, and adipose tissue differentiation markers may suggest a functional role of galectin-1 in obesity.
Study context
- Population
- Participants aged 50 years in the POEM study (Prospective investigation of Obesity, Energy and Metabolism)
- Participants
- 502 participants
- Outcome
- Association profiles of circulating galectin-1 and galectin-3 with metabolic markers
Methodological detailsmulti-omics, association study
- Multi-omics
- Association study
Main finding
As reported in the abstract
- Galectin-1 and galectin-3 associated with fatty acids, lipoproteins and TG incl. lipid measurements in metabolomics analysis adjusted for body mass index (BMI)
- Galectin-1 associated with several measures of adiposity, insulin secretion and insulin sensitivity
- Galectin-3 associated with triglyceride-glucose index (TyG) and fasting insulin
- Both galectins associated with inflammatory pathways and FABP4- and FABP5-regulated TG metabolic pathways
- Galectin-1 also associated with several proteins related to adipose tissue differentiation
Observational data: associations, not effects.
Original publication
Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study. Int J Obes (Lond). Published 22 May 2024. doi:10.
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