An epigenome-wide association study of waist circumference in Chinese monozygotic twins
Authors' conclusion
Our research has ascertained an association between specific epigenetic variations and WC in the Northern Han Chinese population. These DNA methylation features can offer fresh insights into the epigenetic regulation of obesity and WC as well as hints to plausible biological mechanisms.
Study context
- Population
- Waist circumference (WC)-discordant monozygotic twin pairs (ΔWC >0), Qingdao Twin Registry, Northern Han Chinese59 twin pairs
- Outcome
- DNA methylation sites associated with WC
Methodological detailsdiscordant monozygotic twin design, validation stage
- Discordant monozygotic twin design
- Validation stage
Performance
As reported in the abstract
DNA methylation associated with WC
Differentially methylated CpG sites strongly linked to WC (false discovery rate (FDR) < 0.05)
26
Differentially methylated regions strongly linked to WC (slk-corrected p < 0.05)
22
Genes annotated, notably MMP17, ITGA11, COL23A1, TFPI, A2ML1-AS1, MRGPRE, C2orf82, NINJ2
26
Further findings
Causal relationships (ICE FALCON)
- DNA methylation of ITGA11 and TFPI had a causal effect on WC and vice versa
- P < 0.05
Validation analysis
- Sites replicated (p < 0.05) out of 26 identified
- 10
Original publication
An epigenome-wide association study of waist circumference in Chinese monozygotic twins. Int J Obes (Lond). Published 21 May 2024. doi:10.
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