Metabolic Profiles of Pregnancy With Polycystic Ovary Syndrome: Insights into Maternal-Fetal Metabolic Communication
An erratum to this article was published (J Clin Endocrinol Metab, 19 May 2025 ↗)
Authors' conclusion
This study identifies the metabolomic profile and key pathways in maternal-fetal communication during PCOS pregnancies.
Study context
- Population
- Uncomplicated polycystic ovary syndrome (PCOS) pregnancies and normal pregnancies; placenta and umbilical cord serum analysed
- Participants
- 45 vs 50
- Comparison
- PCOS pregnancies vs normal pregnancies
- PCOSn = 45
- Normaln = 50reference
- Outcome
- Metabolic characteristics at the maternal-fetal interface in PCOS pregnancies and the underlying mechanisms
Methodological detailsgas chromatography-mass spectrometry metabolomics
- Gas chromatography-mass spectrometry metabolomics
Main finding
As reported in the abstract
Differential metabolites, PCOS vs normal pregnancies
- Placental metabolites differing significantly
- 79
- Umbilical cord serum metabolites differing significantly
- 25
- Top 10 placental metabolites (ROC) correlating significantly with maternal serum testosterone
- 9
- Lasso-selected placental combination (GABA, proline, glycine, isoleucine): AUC
- 93.24%
- Umbilical cord serum metabolites differing significantly (highest AUC 76.07%)
- 6
- Of these, correlated significantly with maternal serum testosterone
- 5
- Differential metabolites shared between placenta and umbilical cord serum (shared pathways incl. ABC transporters, aminoacyl-tRNA biosynthesis)
- 9
Original publication
Metabolic Profiles of Pregnancy With Polycystic Ovary Syndrome: Insights into Maternal-Fetal Metabolic Communication. J Clin Endocrinol Metab. Published 29 January 2025. doi:10.
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