Metabolic interactions between organs in overweight and obesity using total-body positron emission tomography
Authors' conclusion
Overweight/obese individuals exhibit metabolic alterations in organ level, and altered metabolic interactions at the systemic level. The proposed approach using total-body PET imaging can reveal individual metabolic variability and metabolic deviations between organs, which would open up a new path for understanding metabolic alterations in overweight and obesity.
Study context
- Population
- Adults with normal weight or overweight/obesity undergoing whole-body 18F-FDG positron emission tomography (PET)
- Participants
- 26 vs 30
- Exposure
- Overweight/obese vs normal weight adults
- Overweight/obesen = 26
- Normal weightn = 30reference
- Outcome
- Metabolic network connectivity strength
Methodological detailstotal-body PET imaging (uEXPLORER), covariance network approach
- Total-body PET imaging (uEXPLORER)
- Covariance network approach
Main finding
As reported in the abstract
- Altered network connectivity strength in four nodes (pancreas, spleen, visceral adipose tissue (VAT), bone) in overweight/obese vs normal weight
- Between Overweight/obese and Normal weight: P = 0.033
- Between Overweight/obese and Normal weight: P = 0.021
- Between Overweight/obese and Normal weight: P = 1.12 × 10-5
- Between Overweight/obese and Normal weight: P = 0.021
Observational data: associations, not effects.
Further findings
Correlation of network deviations from normal weight with body mass index (BMI) (overweight/obese)
- Positive correlation, r
- 0.718
- P
- P = 3.64 × 10-5
Altered inter-organ connections
- Overweight/obese had altered connections between organs; some, incl. pancreas-right lung and VAT-bilateral lung, significantly correlated with BMI
Original publication
Metabolic interactions between organs in overweight and obesity using total-body positron emission tomography. Int J Obes (Lond). Published 10 October 2023. doi:10.
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